Maomao, an apothecary's daughter, has been plucked from her peaceful life and sold to the lowest echelons of the imperial court. Now merely a maid, Maomao settles into her new mundane life and hides her extensive knowledge of medicine in order to avoid any unwanted attention. Not long after Maomao's arrival, the emperor's infant children inexplicably begin to experience grave symptoms—almost as if a curse has been cast. The curious Maomao easily solves the mystery and, to remain out of the limelight, attempts to leave an anonymous tip. Unfortunately, the dashing and perceptive eunuch Jinshi sees through it and manages to single her out. In recognition of her talent, Maomao is promoted to lady-in-waiting for the emperor's favorite concubine, Gyokuyou. As Maomao continues to remedy the numerous ailments afflicting the imperial court, her pharmaceutical expertise quickly proves indispensable. [Written by MAL Rewrite]

Using her wit and vast knowledge of medicines and poisons alike, Maomao played a pivotal role in solving a series of mysteries and conspiracies that plagued the imperial court. Having recently come to terms with the secrets of her parents, she returns to fulfill her normal duties on behalf of the emperor's highest-ranking consorts. Maomao also works alongside the eunuch Jinshi to better the consorts' many ladies-in-waiting, including helping them learn to read. However, with the arrival of a merchant caravan comes a new wave of intrigue. A pattern of strange coincidences involving the visitors and their wares unsettles Maomao, driving her to investigate the puzzling circumstances behind the convoy. As dangers from both outside and within threaten the balance between the imperial concubines, Maomao continues to utilize her cunning and medical expertise to keep the women safe from harm. [Written by MAL Rewrite]

Shirayuki and Zen Wistalia have finally confirmed their romantic feelings for each other, and everyone has resumed their daily lives. Shirayuki remains an apprentice court herbalist at the royal palace of Clarines, and Zen continues his duties alongside his aides. However, their daily routines are disrupted when Crown Prince Izana, Zen’s older brother, receives an invitation from Raji Shenazard, the prince of Tanbarun. The herbalist finds herself ordered to go to Tanbarun for seven days, to build a new friendship with the formerly selfish and haughty ruler who once ordered Shirayuki to become his concubine. Along the way, Shirayuki is bound to run into trouble once again, as she is sought by a mysterious boy named Kazuki, someone she has never met. [Written by MAL Rewrite]

The world of psychology is far from strange to the unusual Dr. Ichirou Irabu, a resident psychiatrist of Irabu General Hospital. He and his charming nurse Mayumi run through several patients, each suffering from a mental illness that harms their everyday life. Patients should be wary of the seductive Mayumi, with her spellbinding looks and devilishly short pink nurse uniform. On the other hand, the doctor seems to have three separate personalities: a child with an oversized lab coat; an intelligent, youthful man with feminine traits; and a selfish, outgoing green bear. While curing his patients in questionable ways, Dr. Irabu often tries to gain something from them outside of his profession—and in doing so, occasionally forgets his role as a doctor. As each patient struggles to face the nature of their distress, an obvious yet invisible thread ties their paths together. [Written by MAL Rewrite]

Although her name means "snow white," Shirayuki is a cheerful, red-haired girl living in the country of Tanbarun who works diligently as an apothecary at her herbal shop. Her life changes drastically when she is noticed by the silly prince of Tanbarun, Prince Raji, who then tries to force her to become his concubine. Unwilling to give up her freedom, Shirayuki cuts her long red hair and escapes into the forest, where she is rescued from Raji by Zen Wistalia, the second prince of a neighboring country, and his two aides. Hoping to repay her debt to the trio someday, Shirayuki sets her sights on pursuing a career as the court herbalist in Zen's country, Clarines. Akagami no Shirayuki-hime depicts Shirayuki's journey toward a new life at the royal palace of Clarines, as well as Zen's endeavor to become a prince worthy of his title. As loyal friendships are forged and deadly enemies formed, Shirayuki and Zen slowly learn to support each other as they walk their own paths. [Written by MAL Rewrite]

Kuroo Hazama, also known as "Black Jack," is a legend in the medical world. Famous for being one of the best, as well as not having a license, Hazama and his assistant Pinoko save countless lives that other doctors cannot... for a price; an exorbitant price, in fact, which causes many to view the genius as greedy and heartless. Despite these claims, however, none can deny his skill and the lengths that he will go to treat his patients. This dark medical drama tells the story of the ominous and mysterious world of underground medicine as Black Jack risks his life to cure some of the most bizarre diseases imaginable, even if it means breaking every law in the process. [Written by MAL Rewrite]

Black Jack is an "unregistered" doctor with a clouded, mysterious past. He works with his little assistant Pinoko (who has a massive crush on the doctor), dealing with medical cases not very well known, which can be strange, dangerous, or not known at all. But he is a genius, and can save almost any of his patients' life (as long as they have the money for it, that is), and is known to many around the world, especially to those of medicine and science. He's a man of science himself, and does not believe much until he has seen it, yet it is many times he is surprised by love and nature often overpowering the science he bases his life in. (Source: ANN)

Inside the human body, roughly 37.2 trillion cells work energetically 24 hours a day and 365 days a year. Fresh out of training, the cheerful and somewhat airheaded Sekkekkyuu AE3803 is ready to take on the ever-so-important task of transporting oxygen. As usual, Hakkekkyuu U-1146 is hard at work patrolling and eliminating foreign bacteria seeking to make the body their new lair. Elsewhere, little platelets are lining up for a new construction project. Dealing with wounds and allergies, getting lost on the way to the lungs, and bickering with similar cell types, the daily lives of cells are always hectic as they work together to keep the body healthy! [Written by MAL Rewrite]

No direct-relation sequel to original Black Jack. Black Jack attempts to find out the conspiracy, of why he was involved in the bombfield accident that killed his mother, while he uncovers secrets of Organization and Project "Noir", which, his father and other famous doctors were involved in...

Due to poor lifestyle choices, a certain human's body is in constant turmoil. With germs, bacteria, and foreign substances abound, the jobs of various cells become increasingly difficult and dangerous. As some of the unfortunate ones who matured in this chaotic environment, Sekkekkyuu AA2153 and Hakkekkyuu U-1196 strive to fulfill their duties—even if it means seeing many of their fellow cells lose their lives in duty. Set in an environment vastly different from its parent story, Hataraku Saibou Black portrays the cells' struggles as they try to maintain the body's health. However, the human's condition continues to deteriorate, and whether or not these efforts will amount to something concrete depends on the cells! [Written by MAL Rewrite]

The king of Slantania has officially appointed Sei Takanashi as the Holy Saint—an omnipotent maiden summoned from another world to save the kingdom. After months of relentless fighting against monsters, Sei can finally relax and continue her study at the Medicinal Flora Research Institute. Although her relationship with Albert Hawke, the commander of the Third Order of Knights, gradually blossoms, her bachelorette status attracts unwanted attention from other men—much to Albert's dismay. Moreover, Tenyuu—one of the many princes from the faraway Zaidera Empire—has taken an interest in Slantania and its powerful healing potions. Given that Sei's identity is a national secret, she must lay low in the royal palace until Tenyuu satisfies his curiosity at the institute and returns to his country. Despite his unimpressive appearance, the foreign prince is far from clueless. He has come to Slantania for a clear reason, and Sei's unique skills may just hold the answer to his cryptic research. [Written by MAL Rewrite]

The cells of the human body never rest for too long; there's always something new to do and learn every day. At least, that's what Hakkekkyuu U-1146 feels as he rushes to and fro, searching for any pathogens that could cause harm to the body. Despite his dangerous line of work, it's all worth it to protect the happy smiles of Sekkekkyuu AE3803, the platelet crew, his fellow neutrophils, and the other cells he meets along the way. In his latest pathogen-hunting adventures, Hakkekkyuu U-1146 discovers how important cells can sometimes make mistakes, and that not all bacteria are actually bad. Everybody has their bad days, but everything eventually works out when their comrades have their backs. In the end, it's just another normal day for these hardworking cells! [Written by MAL Rewrite]

Ippan Saibou is envious of the public praise immune system cells like white blood cells receive for protecting the human body from deadly pathogens. Instead of watching safely from his home, he also wants to be useful and get recognized for his efforts. He soon comes across a group of infantile-looking bacteria getting washed away by a river current. Despite knowing the potential dangers that they hold, he rescues the bacteria and brings them to safety. However, Hakkekkyuu U-1146 picks up the presence of these bacteria and is on the hunt for them. Meanwhile, somewhere else in the human body is NK Saibou, who is on the lookout for someone. Based on her intel, he is an antigen that the immune system cells have previously encountered, and he may have returned for revenge. [Written by MAL Rewrite]

Joe Carol Brane attempts to hire Dr. Black Jack on a breed of superhumans that have the strength, intellectual, athletic, and artistic skills with great excel in different fields, only to later find out that they start deteriorating after some period of time and causing an untimely death. Joe needs Dr. Black Jack's help on finding a cure. (Source: ANN)

Since ancient times, the citizens of Slantania have lived within a shroud of miasma, a force that brings forth monsters creating havoc around the world. When the kingdom's Order of Knights becomes incapable of containing the monsters, the Grand Magus summons a holy maiden—the legendary "Saint"—to obliterate the horrid creatures and restore peace. One evening, as Sei Takanashi returns home from a long day at work, a magical force pulls her into a foreign world. Upon her arrival to the kingdom of Slantania, she overhears that the Grand Magus inadvertently summoned two Saints—Sei and a brown-haired girl. Needing only one holy maiden, the prince declares the other girl as the Saint, leaving Sei to her own devices. Sei sets her sight on the Medicinal Flora Research Institute, an establishment known for its studies regarding herbs and potions. While indulging in her latest passion, Sei has a fateful encounter with the commander of the Third Order of Knights. But little does she know, her aptitude as a Saint will continue to exert its influence over her new life. [Written by MAL Rewrite]

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class. [Written by MAL Rewrite]

In her first life, the renowned and genius surgeon Dr. Aoi Takamoto was Elise de Clorance, a villainess of noble descent. Elise's selfishness, insolence, and obsessive love for her fiancé—Prince Linden de Romanoff—led to the deaths of her family members and, eventually, herself. Only after being reborn did Elise realize the error of her ways and decide that, instead of ruining lives, she would devote herself to saving them. But a tragic airplane crash robs her of her dreams too soon. By a miracle, Elise wakes up in her original body before her official engagement to Linden. Recognizing the chance to cherish her loving family and free Linden from an unwanted marriage, Elise wishes to use her advanced medical knowledge to continue down the path of saving lives. In a deal with the emperor, Elise is given only six months to prove that her true place is not on the throne, but rather with the wounded and ailing who desperately need her help. [Written by MAL Rewrite]

For the regular cells of the human body, life consists of countless repetitive tasks. They spend every day multiplying, leaving little time for other activities. But one day, this monotony is abruptly interrupted by a cell with an odd-looking hat. Tired of unending drudgery, another cell named Ippan Saibou decides to join this quirky stranger for a day of pranks, jokes, and mischief. [Written by MAL Rewrite]

Black Jack is the "Surgeon with the Hands of God," a mysterious young Japanese doctor who travels the world performing feats of miraculous surgical genius. Though all recognize his skill, Black Jack is widely hated, especially by the medical establishment, because he refuses to conform to rules of any kind, and because he charges outrageous fees for his services. Black Jack's only companion is Pinoko, a child he created out of a special kind of tumor called a teratoma, who insists she is his wife.

In the 1960s, a gifted young medical student tries to make a name for himself. Kuroo Hazama is a reserved young man with unusual black-and-white hair, a body covered with scars, and a dark past. Despite only being a medical student, his surgical brilliance starts to attract attention after he completes a seemingly impossible operation. Together with the spirited and honest intern Maiko Okamoto and Yabu, a close friend with a troubled life, Hazama devotes himself to the world of medicine. However, his path to becoming a respectable surgeon is a difficult one as student riots, war, and corruption are consuming Japan. Hazama quickly finds himself caught up in a series of nefarious circumstances that challenge his integrity as a person and his path towards becoming a surgeon. Young Black Jack chronicles the story of a man capable of performing unthinkable feats of medicine, and the journey that leads him to become the legend known as Black Jack. [Written by MAL Rewrite]

The series "Once Upon a Time... Life" teaches about the human body and about the different systems in it with the same characters from the other "Once Upon a Time" seasons. "The good Characters" represent the body's defense mechanisms, whereas "the bad Characters" represent the viruses and bacteria that threaten to attack the human body. (Source: Wikipedia)